Research on 1-methylnicotinamide (1-MNA) has been published in numerous peer-reviewed international journals. Selected publications include studies conducted by independent research groups across multiple scientific and academic institutions worldwide.

Endothelial Function & Cardiovascular Biology

Nitric Oxide and Endothelial Function

Hypertension
Research demonstrating the effects of 1-MNA on nitric oxide bioavailability and endothelium-dependent vasorelaxation in human blood vessels.

Anti-Thrombotic Mechanisms of 1-MNA

British Journal of Pharmacology
Study describing prostacyclin-mediated anti-thrombotic mechanisms associated with 1-MNA activity.

Prevention of Endothelial Dysfunction

Pharmacological Reports
Experimental studies investigating the effects of 1-MNA on vascular dysfunction associated with metabolic disorders.

Antiatherosclerotic Effects of 1-MNA

Journal of Pharmacology and Experimental Therapeutics
Research evaluating antiatherosclerotic activity of 1-MNA in experimental cardiovascular disease models.

Metabolism, NAD Biology & Aging Research

Sirtuins and Lifespan Regulation

Nature
Research linking lifespan regulation pathways with nicotinamide methylation and NAD-related metabolic mechanisms.

NNMT and Age-Related Biology

Metabolites
Review discussing the biological role of NNMT and its relevance in aging and age-related conditions.

NNMT Regulation of Hepatic Metabolism

Nature Medicine
Research demonstrating the role of NNMT in hepatic nutrient metabolism and Sirt1 stabilization pathways.

Translational & Clinical Research

Exercise Capacity and Endothelial Response

PLoS ONE
Experimental studies investigating vascular and exercise-related effects of 1-MNA in diabetic models.

Post-COVID Fatigue and Exercise Tolerance

Nutrients
Clinical observations evaluating the effects of 1-MNA on fatigue and exercise tolerance following COVID-19.

Neuroinflammation Research

Neuroprotective Effects of 1-MNA

Journal of Neuroimmune Pharmacology
Preclinical research investigating the effects of 1-MNA on neuroinflammation and cognitive function.